A systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: An EPCRC cachexia guidelines project

dc.contributor.authorRies, Anke
dc.contributor.authorTrottenberg, Peter
dc.contributor.authorElsner, Frank
dc.contributor.authorStiel, Stephanie
dc.contributor.authorHaugen, Dagny
dc.contributor.authorKaasa, Stein
dc.contributor.authorRadbruch, Lukas
dc.date.accessioned2013-07-09
dc.date.available2023-10-06T14:14:16Z
dc.date.created2012
dc.date.issued2013-07-09
dc.description.abstractBackground: The European Palliative Care Research Collaboration is developing clinical guidelines on cachexia in patients with advanced cancer. A systematic review on the use of fish oil/omega-3-fatty acids (n-3-FA)/eicosapentaenoic acids (EPA) in advanced cancer patients suffering from cancer cachexia was performed as part of the guideline development. Methods: The systematic literature search in Medline on the use of fish oil/n-3-FA/EPA identified 244 papers, with 38 publications included in the final evaluation. Some smaller trials, often unrandomized and without a control group, reported a good effect of n-3-FA in patients with advanced cancer and cachexia. However, the results of the larger randomized controlled trials could not support the positive results, as they mostly did not find a significant effect. Results: Adverse effects such as abdominal discomfort, fish belching, fish aftertaste, nausea and diarrhoea were reported with a low incidence. No serious adverse effects were documented, but adverse effects often had an impact on quality of life. This often limited dose escalations or even led to discontinuation of n-3-FA. Conclusion: There is not enough evidence to support a net benefit of n-3-FA in cachexia in advanced cancer. On the other hand, adverse effects were infrequent, with no severe adverse effects. The results from the review led to a weak negative GRADE recommendation.en
dc.identifier.citationPalliative Medicine 26.4 (2012): S. 294-304. 01.07.2013 <http://pmj.sagepub.com/content/26/4/294.abstract>
dc.identifier.doihttps://doi.org/10.1177/0269216311418709
dc.identifier.opus-id3468
dc.identifier.urihttps://open.fau.de/handle/openfau/3468
dc.identifier.urnurn:nbn:de:bvb:29-opus-48090
dc.language.isoen
dc.rights.urihttp://www.gesetze-im-internet.de/urhg/index.html
dc.subjectCancer cachexia
dc.subjecteicosapentaenoic acids
dc.subjectfish oil
dc.subjectguidelines
dc.subjectomega-3-fatty acids
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleA systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: An EPCRC cachexia guidelines projecten
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.journal.titlePalliative Medicine 26.4 (2012): S. 294-304. 01.07.2013 <http://pmj.sagepub.com/content/26/4/294.abstract>
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät / Medizinische Fakultät -ohne weitere Spezifikation-
local.subject.gnd-
local.subject.sammlungUniversität Erlangen-Nürnberg / Allianzlizenzen: Alle Beiträge sind mit Zustimmung der Rechteinhaber aufgrund einer DFG-geförderten Allianzlizenz frei zugänglich. / Allianzlizenzen 2012
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