Basic Human Body Dimensions Relate to Alcohol Dependence and Predict Hospital Readmission

dc.contributor.authorLenz, Bernd
dc.contributor.authorKöllner, Martin G.
dc.contributor.authorMühle, Christiane
dc.contributor.authorWeinland, Christian
dc.contributor.authorKornhuber, Johannes
dc.date.accessioned2020-01-09
dc.date.available2023-10-10T00:01:44Z
dc.date.created2019
dc.date.issued2020-01-09
dc.description.abstractAlcohol dependence is a severe mental illness and there is a need for more effective preventive and therapeutic strategies. Translational research suggests that intrauterine sex hormone exposure modulates the risk and course of alcohol dependence during adulthood. During development, sex hormones permanently shape sexually dimorphic body dimensions. Thus, these dimensions may provide insight into sex hormone organization. Here, we compared body measurements (absolute, relative to, and residualized on height) between 200 alcohol-dependent in-patients and 240 age-matched healthy control subjects and investigated how these measurements associate with the patients’ prospective 12- and 24-month outcome. The results show that alcohol dependence is related to lower absolute, relative, and residualized body measurements for height and weight, head circumference, bitragion head arc, lip-chin distance, hip, thigh, and calf circumference, and foot length and breadth. In male alcohol-dependent in-patients, higher risk, shorter latency, and more alcohol-related readmissions were predicted by higher absolute, relative, and residualized thigh and calf circumferences. The second-to-fourth finger length ratio, a putative proxy for prenatal sex hormone organization, was not convincingly correlated with the body dimensions, suggesting that the results represent pubertal (or later) effects. The study’s findings have implications for further research. The body measurements’ high accessibility may facilitate the future transition into clinical settings.en
dc.identifier.citationJournal of Clinical Medicine 8.12 (2019): 2076. <https://doi.org/10.3390/jcm8122076>
dc.identifier.doihttps://doi.org/10.3390/jcm8122076
dc.identifier.issn2077-0383
dc.identifier.opus-id12599
dc.identifier.urihttps://open.fau.de/handle/openfau/12599
dc.identifier.urnurn:nbn:de:bvb:29-opus4-125999
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.de
dc.subjectAlcohol Dependence
dc.subjectRelapse Prediction
dc.subjectBody Measurements
dc.subjectBody Dimensions
dc.subjectOrganizational Sex Hormone Effects
dc.subjectAnthropometry
dc.subjectPubertal Hormones
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleBasic Human Body Dimensions Relate to Alcohol Dependence and Predict Hospital Readmissionen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.date.prevpublished2019-11-27
local.journal.issue12
local.journal.titleJournal of Clinical Medicine
local.journal.volume8
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät
local.subject.importimport
local.subject.sammlungUniversität Erlangen-Nürnberg / Von der FAU geförderte Open Access Artikel / Von der FAU geförderte Open Access Artikel 2019
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