Cerebrospinal Fluid Neurochemical Phenotypes in Vascular Dementias: Original Data and Mini-Review

Language
en
Document Type
Article
Issue Date
2013-03-14
Issue Year
2007
Authors
Bibl, Mirko
Mollenhauer, Brit
Esselmann, Hermann
Schneider, Michael
Lewczuk, Piotr
Welge, Volker
Gross, Martin
Falkai, Peter
Kornhuber, Johannes
Wiltfang, Jens
Editor
Abstract

Background/Aims: The study evaluated the patterns of cerebrospinal fluid (CSF), amyloid- _ (A _ ) peptides, total tau and phospho-tau among Alzheimer’s disease (AD) and vascular dementias (VAD). Methods: A _ -SDS-PAGE immunoblot and commercially available ELISAs were applied to the CSF analysis of 52 patients with probable (n = 21) and possible (n = 16) VAD, AD with cerebrovascular disease (n = 15), 30 patients with probable AD and 30 nondemented disease controls. Results: AD and AD with cerebrovascular disease displayed a similar neurochemical phenotype in contrast to nondemented disease controls and probable VAD with regard to tau, p-tau, A _ 1–40 ox and A _ 1–42%. Possible VAD displayed AD-like changes only for A _ 1–40 ox and A _ 1–42%. Conclusion: CSF neurochemical phenotypes sufficiently discriminate probable AD and VAD from each other, but their diagnostic value is limited in case of no clear-cut clinical ap- pearance, such as possible VAD. Conversely, CSF A _ peptides and p-tau levels may help estimate the involvement of ADlike pathophysiological pathways in VAD subgroups.

Journal Title
Dementia and Geriatric Cognitive Disorders 2008; 25: 256-265. <http://content.karger.com/ProdukteDB/produkte.asp?typ=pdf&doi=115975> © 2008 S. Karger AG, Basel
Citation
Dementia and Geriatric Cognitive Disorders 2008; 25: 256-265. <http://content.karger.com/ProdukteDB/produkte.asp?typ=pdf&doi=115975> © 2008 S. Karger AG, Basel
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