Demyelinating disease and anti-N-methyl-D-aspartate receptor immunoglobulin G antibodies: a case report

Language
en
Document Type
Article
Issue Date
2015-05-04
Issue Year
2014
Authors
Waschbisch, Anne
Kallmünzer, Bernd
Schwab, Stefan
Gölitz, Philipp
Vincent, Angela
Lee, De-Hyung
Linker, Ralf A.
Editor
Abstract

Background: Anti–N-methyl-D-aspartate receptor immunoglobulin G antibodies directed against the GluN1 subunit are considered highly specific for anti-N-methyl-D-aspartate receptor encephalitis, a severe clinical syndrome characterized by seizures, psychiatric symptoms, orofacial dyskinesia and autonomic dysfunction. Case presentation: Here we report a 33 year old Caucasian male patient with clinically definite multiple sclerosis who was found to be positive for anti-N-methyl-D-aspartate receptor antibodies. Rituximab therapy was initiated. On the 18 months follow-up visit the patient was found to be clinically stable, without typical signs of anti-N-methyl-D-aspartate receptor encephalitis. Conclusion: Our findings add to the growing evidence for a possible association between anti-N-methyl-D-aspartate receptor encephalitis and demyelinating diseases.

Journal Title
BMC Research Notes
Volume
7
Citation

BMC Research Notes 7 (2014):S. 948 - 951. http://www.biomedcentral.com/1756-0500/7/948

DOI
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