Plasma proteomic profiles differ between European and North American myotid bats colonized by Pseudogymnoascus destructans

dc.contributor.authorHecht‐Höger, Alexander M.
dc.contributor.authorBraun, Beate C.
dc.contributor.authorKrause, Eberhard
dc.contributor.authorMeschede, Angelika
dc.contributor.authorKrahe, Rüdiger
dc.contributor.authorVoigt, Christian C.
dc.contributor.authorGreenwood, Alex D.
dc.contributor.authorCzirják, Gábor Á.
dc.date.accessioned2020-12-29
dc.date.available2023-10-11T11:33:24Z
dc.date.created2020
dc.date.issued2020-12-29
dc.description.abstractEmerging fungal diseases have become challenges for wildlife health and conservation. North American hibernating bat species are threatened by the psychrophilic fungus Pseudogymnoascus destructans (Pd) causing the disease called white‐nose syndrome (WNS) with unprecedented mortality rates. The fungus is widespread in North America and Europe, however, disease is not manifested in European bats. Differences in epidemiology and pathology indicate an evolution of resistance or tolerance mechanisms towards Pd in European bats. We compared the proteomic profile of blood plasma in healthy and Pd‐colonized European Myotis myotis and North American Myotis lucifugus in order to identify pathophysiological changes associated with Pd colonization, which might also explain the differences in bat survival. Expression analyses of plasma proteins revealed differences in healthy and Pd‐colonized M. lucifugus, but not in M. myotis. We identified differentially expressed proteins for acute phase response, constitutive and adaptive immunity, oxidative stress defence, metabolism and structural proteins of exosomes and desmosomes, suggesting a systemic response against Pd in North American M. lucifugus but not European M. myotis. The differences in plasma proteomic profiles between European and North American bat species colonized by Pd suggest European bats have evolved tolerance mechanisms towards Pd infection.en
dc.format.extent10
dc.identifier.citationMolecular Ecology 29.9 (2020): S. 1745-1755. <https://onlinelibrary.wiley.com/doi/full/10.1111/mec.15437>
dc.identifier.doihttps://doi.org/10.1111/mec.15437
dc.identifier.opus-id15237
dc.identifier.urihttps://open.fau.de/handle/openfau/15237
dc.identifier.urnurn:nbn:de:bvb:29-opus4-152372
dc.language.isoen
dc.publisherJohn Wiley & Sons Ltd
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.de
dc.subjecthibernation
dc.subjectintercontinental differences
dc.subjectresistance
dc.subjecttolerance
dc.subjectwhite‐nose syndrome
dc.subject.ddcDDC Classification::5 Naturwissenschaften und Mathematik :: 57 Biowissenschaften; Biologie :: 570 Biowissenschaften; Biologie
dc.titlePlasma proteomic profiles differ between European and North American myotid bats colonized by Pseudogymnoascus destructansen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.date.prevpublished2020-06-07
local.document.pageend1755
local.document.pagestart1745
local.journal.issue9
local.journal.titleMolecular Ecology
local.journal.volume29
local.sendToDnbfree*
local.subject.fakultaetNaturwissenschaftliche Fakultät
local.subject.importimport
local.subject.sammlungUniversität Erlangen-Nürnberg / Eingespielte Open Access Artikel / Eingespielte Open Access Artikel 2020
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