Atrial Natriuretic Peptide, Arginine Vasopressin Peptide and Cortisol Serum Levels in Opiate-Dependent Patients

Language
en
Document Type
Article
Issue Date
2014-05-05
Issue Year
2013
Authors
Glahn, Alexander
Heberlein, Annemarie
Dürsteler-MacFarland, Kenneth M.
Lenz, Bernd
Frieling, Helge
Gröschl, Michael
Wiesbeck, Gerhard A.
Kornhuber, Johannes
Bönsch, Dominikus
Bleich, Stefan
Editor
Abstract

Preclinical studies suggest that chronic drug abuse profoundly alters stress-responsive systems. The best studied of the stress-responsive systems in humans is the hypothalamic- pituitary-adrenal (HPA) axis. Apart from cortisol, arginine vasopressin peptide (AVP), and atrial natriuretic peptide (ANP) are known to directly impact upon the HPA axis in addictive behavior. We investigated alterations in ANP, AVP and cortisol serum levels in opiate-dependent patients who received diacetylmorphine treatment within a structured opiate maintenance program. ANP serum levels were significantly increased in opiate-dependent patients as compared to healthy controls, whereas AVP and cortisol serum levels were reduced. The ANP, AVP and cortisol serum levels were not significantly associated with the psychometric dimensions of heroin craving. In conclusion, chronic drug abuse profoundly alters stress-responsive systems like the HPA axis. Alterations of AVP, ANP and cortisol appear to constitute an important component in the neurobiology of opiate-dependent patients.

Journal Title
Neuropsychobiology
Volume
67
Citation
Neuropsychobiology 2013; 67: 111-115. <http://www.karger.com/Article/Pdf/346110> © 2013 S. Karger AG, Basel
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