Topical VEGF-C/D Inhibition Prevents Lymphatic Vessel Ingrowth into Cornea but Does Not Improve Corneal Graft Survival

dc.contributor.authorSalabarria, Ann-Charlott
dc.contributor.authorKoch, Manuel
dc.contributor.authorSchönberg, Alfrun
dc.contributor.authorZinser, Elisabeth
dc.contributor.authorHos, Deniz
dc.contributor.authorHamdorf, Matthias
dc.contributor.authorImhof, Thomas
dc.contributor.authorBraun, Gabriele
dc.contributor.authorCursiefen, Claus
dc.contributor.authorBock, Felix
dc.date.accessioned2020-05-07
dc.date.available2023-10-09T23:23:38Z
dc.date.created2020
dc.date.issued2020-05-07
dc.description.abstractVascular endothelial growth factor-C/D (VEGF-C/D) regulates lymphangiogenesis. Ingrowth of lymphatic vessels is negatively associated with corneal transplantation success. In this study, we therefore analyzed the effect local blockade of VEGF-C/D has on inflamed corneas. We used the murine model of suture-induced neovascularization and subsequent high-risk corneal transplantation. Mice were treated with a VEGF-C/D trap prior to transplantation. Topical inhibition of VEGF-C/D significantly reduced lymphatic vessel ingrowth, but increased Macrophage numbers in the cornea. Furthermore, corneal transplantation success was not improved by the topical application of the compound. This study demonstrates that local VEGF-C/D inhibition is insufficient to increases corneal transplantation success, likely due to interaction with immune cells.en
dc.identifier.citationJournal of Clinical Medicine 9.5 (2020): 1270. <https://www.mdpi.com/2077-0383/9/5/1270/htm>
dc.identifier.doihttps://doi.org/10.3390/jcm9051270
dc.identifier.issn2077-0383
dc.identifier.opus-id13696
dc.identifier.urihttps://open.fau.de/handle/openfau/13696
dc.identifier.urnurn:nbn:de:bvb:29-opus4-136969
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.de
dc.subjectVEGF C/D trap
dc.subjectcorneal transplantation
dc.subjectlocal immune modulation
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleTopical VEGF-C/D Inhibition Prevents Lymphatic Vessel Ingrowth into Cornea but Does Not Improve Corneal Graft Survivalen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.date.prevpublished2020-04-28
local.journal.issue5
local.journal.titleJournal of Clinical Medicine
local.journal.volume9
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät
local.subject.importimport
local.subject.sammlungUniversität Erlangen-Nürnberg / Eingespielte Open Access Artikel / Eingespielte Open Access Artikel 2020
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