Topical VEGF-C/D Inhibition Prevents Lymphatic Vessel Ingrowth into Cornea but Does Not Improve Corneal Graft Survival

Language
en
Document Type
Article
Issue Date
2020-05-07
First published
2020-04-28
Issue Year
2020
Authors
Salabarria, Ann-Charlott
Koch, Manuel
Schönberg, Alfrun
Zinser, Elisabeth
Hos, Deniz
Hamdorf, Matthias
Imhof, Thomas
Braun, Gabriele
Cursiefen, Claus
Bock, Felix
Editor
Publisher
MDPI
Abstract

Vascular endothelial growth factor-C/D (VEGF-C/D) regulates lymphangiogenesis. Ingrowth of lymphatic vessels is negatively associated with corneal transplantation success. In this study, we therefore analyzed the effect local blockade of VEGF-C/D has on inflamed corneas. We used the murine model of suture-induced neovascularization and subsequent high-risk corneal transplantation. Mice were treated with a VEGF-C/D trap prior to transplantation. Topical inhibition of VEGF-C/D significantly reduced lymphatic vessel ingrowth, but increased Macrophage numbers in the cornea. Furthermore, corneal transplantation success was not improved by the topical application of the compound. This study demonstrates that local VEGF-C/D inhibition is insufficient to increases corneal transplantation success, likely due to interaction with immune cells.

Journal Title
Journal of Clinical Medicine
Volume
9
Issue
5
Citation
Journal of Clinical Medicine 9.5 (2020): 1270. <https://www.mdpi.com/2077-0383/9/5/1270/htm>
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