Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?

dc.contributor.authorWessler, Silja
dc.contributor.authorSchneider, Gisbert
dc.contributor.authorBackert, Steffen
dc.date.accessioned2017-07-03
dc.date.available2017-06-12
dc.date.created2017
dc.date.issued2017-07-03
dc.description.abstractRecent studies have demonstrated that the bacterial chaperone and serine protease high temperature requirement A (HtrA) is closely associated with the establishment and progression of several infectious diseases. HtrA activity enhances bacterial survival under stress conditions, but also has direct effects on functions of the cell adhesion protein E-cadherin and extracellular matrix proteins, including fibronectin and proteoglycans. Although HtrA cannot be considered as a pathogenic factor per se, it exhibits favorable characteristics making HtrA a potentially attractive drug target to combat various bacterial infections.en
dc.identifier.citationCell Communication and Signaling 15 (2017). <https://biosignaling.biomedcentral.com/articles/10.1186/s12964-017-0162-5>
dc.identifier.doihttps://doi.org/10.1186/s12964-017-0162-5
dc.identifier.opus-id8574
dc.identifier.urihttps://open.fau.de/handle/openfau/8574
dc.identifier.urnurn:nbn:de:bvb:29-opus4-85741
dc.language.isoen
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/de/deed.de
dc.subject.ddcDDC Classification::5 Naturwissenschaften und Mathematik :: 57 Biowissenschaften; Biologie :: 570 Biowissenschaften; Biologie
dc.titleBacterial serine protease HtrA as a promising new target for antimicrobial therapy?en
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.journal.titleCell Communication and Signaling
local.journal.volume15
local.sendToDnbfree*
local.subject.fakultaetNaturwissenschaftliche Fakultät
local.subject.gnd-
local.subject.sammlungUniversität Erlangen-Nürnberg / Open Access Artikel ohne Förderung / Open Access Artikel ohne Förderung 2017
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