Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?

Language
en
Document Type
Article
Issue Date
2017-07-03
Issue Year
2017
Authors
Wessler, Silja
Schneider, Gisbert
Backert, Steffen
Editor
Abstract

Recent studies have demonstrated that the bacterial chaperone and serine protease high temperature requirement A (HtrA) is closely associated with the establishment and progression of several infectious diseases. HtrA activity enhances bacterial survival under stress conditions, but also has direct effects on functions of the cell adhesion protein E-cadherin and extracellular matrix proteins, including fibronectin and proteoglycans. Although HtrA cannot be considered as a pathogenic factor per se, it exhibits favorable characteristics making HtrA a potentially attractive drug target to combat various bacterial infections.

Journal Title
Cell Communication and Signaling
Volume
15
Citation
Cell Communication and Signaling 15 (2017). <https://biosignaling.biomedcentral.com/articles/10.1186/s12964-017-0162-5>
Zugehörige ORCIDs