Potential of Exosomes for the Treatment of Stroke

Language
en
Document Type
Article
Issue Date
2021-04-22
Issue Year
2019
Authors
Hong, Shi-Bin
Yang, Hua
Manaenko, Anatol
Lu, Jianfei
Mei, Qiyong
Hu, Qin
Editor
Publisher
SAGE Publications
Abstract

Stroke is the result of blockage or rupture of blood vessels in the brain and is the leading cause of death and disability in the world. Currently only a very limited number of therapeutic approaches are available for treatment of stroke patients, and the vast majority of neuroprotective agents that tested positively in pre-clinical studies failed in clinical trials. In recent years, the clinical value of the use of exosomes for stroke treatment has received widespread attention due their unique characteristics such as low immunogenicity, low toxicity and biodegradability, ability to cross the blood–brain barrier (BBB), and their important role in communication between cells. More and more evidence suggests that the secretion of exosomes is the mechanism underlying the protection induced by mesenchymal stromal cells (MSCs) after stroke. Exosomes are thought to support brain restoration and induce repairing effects, including neurovascular remodeling, and anti-apoptosis and anti-inflammatory effects. Recent reports have focused on the clinical application of exosomes as a potential drug delivery approach. This review focuses on the ability of exosomes to interrupt the stroke-induced pathologic processes of stroke, and on publications describing how to achieve more effective treatment of stroke with exosomes.

Journal Title
Cell Transplantation
Volume
28
Issue
6
Citation
Cell Transplantation 28.6 (2019): 662 - 670. <https://journals.sagepub.com/doi/full/10.1177/0963689718816990>
Zugehörige ORCIDs