Novel imaging methods reveal positive impact of topical negative pressure application on tissue perfusion in an in vivo skin model

dc.contributor.authorMüller-Seubert, Wibke
dc.contributor.authorRoth, Sascha
dc.contributor.authorHauck, Theresa
dc.contributor.authorArkudas, Andreas
dc.contributor.authorHorch, Raymund E.
dc.contributor.authorLudolph, Ingo
dc.date.accessioned2022-05-19
dc.date.available2022-05-18
dc.date.created2021
dc.date.issued2022-05-19
dc.description.abstractThe influence of topical negative pressure application (TNPA) on tissue perfusion still remains controversial. TNPA was applied for 30 minutes on intact skin of 21 healthy participants. Measurements of tissue oxygen saturation and tissue temperature as signs of tissue perfusion were performed before application of the TNPA, directly after removal of the TNPA and 5, 10, 15, 20, and 30 minutes after removal of the dressing using the near infrared imaging (NIRI) and a thermal imaging camera. Tissue oxygen saturation showed an increase from 67.7% before applying the TNPA to 76.1% directly after removal of TNPA, followed by a decrease of oxygen saturation 30 minutes after removal of TNPA. The measured temperature of the treated skin area increased from 32.1°C to 36.1°C after removal of TNPA with a consecutive decrease of the temperature 30 minutes after removal. TNPA resulted in both a higher tissue oxygen saturation and a higher skin temperature after 30 minutes compared to the beginning. TNPA increases both tissue oxygen saturation and skin temperature as sign of an increase of tissue perfusion. NIRI and thermal imaging proved to be useful for measuring changes in tissue perfusion.en
dc.format.extent932-939
dc.identifier.citationInternational Wound Journal 18.6 (2021): 932-939. <https://onlinelibrary.wiley.com/doi/full/10.1111/iwj.13639>
dc.identifier.doihttps://doi.org/10.1111/iwj.13639
dc.identifier.opus-id19357
dc.identifier.urihttps://open.fau.de/handle/openfau/19357
dc.identifier.urnurn:nbn:de:bvb:29-opus4-193577
dc.language.isoen
dc.publisherJohn Wiley & Sons
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/deed.de
dc.subjectnear infrared imaging
dc.subjectthermal imaging
dc.subjectissue oxygen saturation
dc.subjecttopical negative pressure application
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleNovel imaging methods reveal positive impact of topical negative pressure application on tissue perfusion in an in vivo skin modelen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.journal.issue6
local.journal.titleInternational Wound Journal
local.journal.volume18
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät
local.subject.sammlungUniversität Erlangen-Nürnberg / Von der FAU geförderte Open Access Artikel / Von der FAU geförderte Open Access Artikel 2021
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