Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain: the report of an expert panel

dc.contributor.authorBurlina, Alessandro P.
dc.contributor.authorSims, Katherine B.
dc.contributor.authorPolitei, Juan M.
dc.contributor.authorBennett, Gary J.
dc.contributor.authorBaron, Ralf
dc.contributor.authorSommer, Claudia
dc.contributor.authorMøller, Anette T.
dc.contributor.authorHilz, Max J.
dc.date.accessioned2012-10-24
dc.date.available2023-10-06T14:19:02Z
dc.date.created2011
dc.date.issued2012-10-24
dc.description.abstractBackground Fabry disease is an inherited metabolic disorder characterized by progressive lysosomal accumulation of lipids in a variety of cell types, including neural cells. Small, unmyelinated nerve fibers are particularly affected and small fiber peripheral neuropathy often clinically manifests at young age. Peripheral pain can be chronic and/or occur as provoked attacks of excruciating pain. Manifestations of dysfunction of small autonomic fibers may include, among others, impaired sweating, gastrointestinal dysmotility, and abnormal pain perception. Patients with Fabry disease often remain undiagnosed until severe complications involving the kidney, heart, peripheral nerves and/or brain have arisen. Methods An international expert panel convened with the goal to provide guidance to clinicians who may encounter unrecognized patients with Fabry disease on how to diagnose these patients early using simple diagnostic tests. A further aim was to offer recommendations to control neuropathic pain. Results We describe the neuropathy in Fabry disease, focusing on peripheral small fiber dysfunction - the hallmark of early neurologic involvement in this disorder. The clinical course of peripheral pain is summarized, and the importance of medical history-taking, including family history, is highlighted. A thorough physical examination (e.g., angiokeratoma, corneal opacities) and simple non-invasive sensory perception tests could provide clues to the diagnosis of Fabry disease. Reported early clinical benefits of enzyme replacement therapy include reduction of neuropathic pain, and adequate management of residual pain to a tolerable and functional level can substantially improve the quality of life for patients. Conclusions Our recommendations can assist in diagnosing Fabry small fiber neuropathy early, and offer clinicians guidance in controlling peripheral pain. This is particularly important since management of pain in young patients with Fabry disease appears to be inadequate.en
dc.identifier.citationBMC Neurology 11.61 (2011): 24.10.2012 <http://www.biomedcentral.com/1471-2377/11/61>
dc.identifier.opus-id2462
dc.identifier.urihttps://open.fau.de/handle/openfau/2462
dc.identifier.urnurn:nbn:de:bvb:29-opus-36355
dc.language.isoen
dc.subjectDiagnosis
dc.subjectFabry Disease
dc.subjectNeuropathy
dc.subjectPain
dc.subjectTreatment
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleEarly diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain: the report of an expert panelen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.journal.titleBMC Neurology 11.61 (2011): 24.10.2012 <http://www.biomedcentral.com/1471-2377/11/61>
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät / Medizinische Fakultät -ohne weitere Spezifikation-
local.subject.gnd-
local.subject.sammlungUniversität Erlangen-Nürnberg / Open Access Artikel ohne Förderung / Open Access Artikel ohne Förderung 2011
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
2462_burlina_early_3635.pdf
Size:
2.14 MB
Format:
Adobe Portable Document Format
Description: