Different Storage Conditions Influence Biocompatibility and Physicochemical Properties of Iron Oxide Nanoparticles

dc.contributor.authorZaloga, Jan
dc.contributor.authorJanko, Christina
dc.contributor.authorAgarwal, Rohit
dc.contributor.authorNowak, Johannes
dc.contributor.authorMüller, Robert
dc.contributor.authorBoccaccini, Aldo R.
dc.contributor.authorLee, Geoffrey
dc.contributor.authorOdenbach, Stefan
dc.contributor.authorLyer, Stefan
dc.contributor.authorAlexiou, Christoph
dc.date.accessioned2016-04-15
dc.date.available2016-04-15
dc.date.created2015
dc.date.issued2016-04-15
dc.description.abstractSuperparamagnetic iron oxide nanoparticles (SPIONs) have attracted increasing attention in many biomedical fields. In magnetic drug targeting SPIONs are injected into a tumour supplying artery and accumulated inside the tumour with a magnet. The effectiveness of this therapy is thus dependent on magnetic properties, stability and biocompatibility of the particles. A good knowledge of the effect of storage conditions on those parameters is of utmost importance for the translation of the therapy concept into the clinic and for reproducibility in preclinical studies. Here, core shell SPIONs with a hybrid coating consisting of lauric acid and albumin were stored at different temperatures from 4 to 45 °C over twelve weeks and periodically tested for their physicochemical properties over time. Surprisingly, even at the highest storage temperature we did not observe denaturation of the protein or colloidal instability. However, the saturation magnetisation decreased by maximally 28.8% with clear correlation to time and storage temperature. Furthermore, the biocompatibility was clearly affected, as cellular uptake of the SPIONs into human T-lymphoma cells was crucially dependent on the storage conditions. Taken together, the results show that the particle properties undergo significant changes over time depending on the way they are stored.en
dc.format.extentS. 9368–9384
dc.identifier.citationInternational Journal of Molecular Sciences 16.5 (2015):S. 9368–9384. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463593/>
dc.identifier.opus-id7052
dc.identifier.urihttps://open.fau.de/handle/openfau/7052
dc.identifier.urnurn:nbn:de:bvb:29-opus4-70524
dc.language.isoen
dc.rights.urihttp://www.gesetze-im-internet.de/urhg/index.html
dc.subjectMagnetic drug targeting, iron oxide nanoparticles
dc.subjectNanomedicine
dc.subjectColloidal stability
dc.subjectNanoparticle stability
dc.subjectIron oxide biocompatibility
dc.subjectMagnetite maghemite biocompatibility
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleDifferent Storage Conditions Influence Biocompatibility and Physicochemical Properties of Iron Oxide Nanoparticlesen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.journal.issue5
local.journal.titleInternational Journal of Molecular Sciences
local.journal.volume16
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät
local.subject.gnd-
local.subject.sammlungUniversität Erlangen-Nürnberg / Von der FAU geförderte Open Access Artikel / Von der FAU geförderte Open Access Artikel 2015
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