Subclinical joint inflammation in patients with psoriasis without concomitant psoriatic arthritis: a cross-sectional and longitudinal analysis

dc.contributor.authorFaustini, Francesca
dc.contributor.authorSimon, David
dc.contributor.authorOliveira, Isabelle
dc.contributor.authorKleyer, Arnd
dc.contributor.authorHaschka, Judith
dc.contributor.authorEnglbrecht, Matthias
dc.contributor.authorRodrigues Cavalcante, Alan
dc.contributor.authorKraus, Sebastian
dc.contributor.authorPonte Tabosa, Taiane
dc.contributor.authorFigueiredo, Camille
dc.contributor.authorHueber, Axel J.
dc.contributor.authorKocijan, Roland
dc.contributor.authorCavallaro, Alexander
dc.contributor.authorSchett, Georg
dc.contributor.authorSticherling, Michael
dc.contributor.authorRech, Jürgen
dc.date.accessioned2018-07-09
dc.date.available2018-06-26
dc.date.created2016
dc.date.issued2018-07-09
dc.description.abstractObjectives To search for subclinical inflammatory joint disease in patients with psoriasis without psoriatic arthritis (PsA), and to determine whether such changes are associated with the later development of PsA. Methods Eighty-five subjects without arthritis (55 with psoriasis and 30 healthy controls) received high field MRI of the hand. MRI scans were scored for synovitis, osteitis, tenosynovitis and periarticular inflammation according to the PsAMRIS method. Patients with psoriasis additionally received complete clinical investigation, high-resolution peripheral quantitative CT for detecting erosions and enthesiophytes and were followed up for at least 1 year for the development of PsA. Results 47% of patients with psoriasis showed at least one inflammatory lesion on MRI. Synovitis was the most prevalent inflammatory lesion (38%), while osteitis (11%), tenosynovitis (4%) and periarticular inflammation (4%) were less frequent. The mean (±SD) PsAMRIS synovitis score was 3.0±2.5 units. Enthesiophytes and bone erosions were not different between patients with psoriasis with or without inflammatory MRI changes. The risk for developing PsA was as high as 60% if patients had subclinical synovitis and symptoms related to arthralgia, but only 13% if patients had normal MRIs and did not report arthralgia. Conclusions Prevalence of subclinical inflammatory lesions is high in patients with cutaneous psoriasis. Arthralgia in conjunction with MRI synovitis constitutes a high-risk constellation for the development of PsA.en
dc.format.extent2068 - 2074
dc.identifier.citationAnnals of the Rheumatic Diseases 75.12 (2016): S. 2068-2074. <http://ard.bmj.com/content/75/12/2068>
dc.identifier.doihttps://doi.org/10.1136/annrheumdis-2015-208821
dc.identifier.opus-id9793
dc.identifier.urihttps://open.fau.de/handle/openfau/9793
dc.identifier.urnurn:nbn:de:bvb:29-opus4-97933
dc.language.isoen
dc.rights.urihttp://www.gesetze-im-internet.de/urhg/index.html
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleSubclinical joint inflammation in patients with psoriasis without concomitant psoriatic arthritis: a cross-sectional and longitudinal analysisen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.journal.issue12
local.journal.titleAnnals of the Rheumatic Diseases
local.journal.volume75
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät
local.subject.gnd-
local.subject.sammlungUniversität Erlangen-Nürnberg / Allianzlizenzen: Alle Beiträge sind mit Zustimmung der Rechteinhaber aufgrund einer DFG-geförderten Allianzlizenz frei zugänglich. / Allianzlizenzen 2016
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