Low Dose Radiation Therapy, Particularly with 0.5 Gy, Improves Pain in Degenerative Joint Disease of the Fingers: Results of a Retrospective Analysis

dc.contributor.authorDonaubauer, Anna-Jasmina
dc.contributor.authorZhou, Jian-Guo
dc.contributor.authorOtt, Oliver J.
dc.contributor.authorPutz, Florian
dc.contributor.authorFietkau, Rainer
dc.contributor.authorKeilholz, Ludwig
dc.contributor.authorGaipl, Udo S.
dc.contributor.authorFrey, Benjamin
dc.contributor.authorWeissmann, Thomas
dc.date.accessioned2021-01-13
dc.date.available2021-01-12
dc.date.created2020
dc.date.issued2021-01-13
dc.description.abstractLow-dose radiation therapy (LDRT) has been successfully established for decades as an alternative analgesic treatment option for patients suffering from chronic degenerative and inflammatory diseases. In this study, 483 patients were undergoing LDRT for degenerative joint disease of the fingers and thumb at the University Hospital Erlangen between 2004 and 2019. Radiotherapy was applied according to the German guidelines for LDRT. Several impact factors on therapeutic success, such as the age and gender, the number of affected fingers, the single and cumulative dose, as well as the number of series, were investigated. In summary, 70% of the patients showed an improvement of their pain following LDRT. No significant impact was found for the factors age, gender, the number of series or the cumulative dosage. Patients with an involvement of the thumb showed a significantly worse outcome compared to patients with an isolated affection of the fingers. In this cohort, patients receiving a single dose of 0.5 Gy reported a significantly better outcome than patients receiving 1.0 Gy, strongly suggesting a reduction in the total dose. In summary, LDRT is a good alternative treatment option for patients suffering from degenerative and inflammatory joint disease of the fingers.en
dc.identifier.citationInternational Journal of Molecular Sciences 21.16 (2020): 5854. <https://www.mdpi.com/1422-0067/21/16/5854>
dc.identifier.doihttps://doi.org/10.3390/ijms21165854
dc.identifier.opus-id15589
dc.identifier.urihttps://open.fau.de/handle/openfau/15589
dc.identifier.urnurn:nbn:de:bvb:29-opus4-155897
dc.language.isoen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.de
dc.subjectlow-dose radiation therapy
dc.subjectLDRT
dc.subjectdegenerative joint disease of the fingers
dc.subjectosteoarthritis
dc.subjectchronic degenerative and inflammatory diseases
dc.subjectsubjective pain level
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleLow Dose Radiation Therapy, Particularly with 0.5 Gy, Improves Pain in Degenerative Joint Disease of the Fingers: Results of a Retrospective Analysisen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.document.articlenumber5854
local.journal.issue16
local.journal.titleInternational Journal of Molecular Sciences
local.journal.volume21
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät
local.subject.sammlungUniversität Erlangen-Nürnberg / Von der FAU geförderte Open Access Artikel / Von der FAU geförderte Open Access Artikel 2020
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