Protection of Batf3‐deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T‐cell responses and immune regulation

dc.contributor.authorKuehlwein, Janina M.
dc.contributor.authorBorsche, Max
dc.contributor.authorKorir, Patricia J.
dc.contributor.authorRisch, Frederic
dc.contributor.authorMueller, Ann‐Kristin
dc.contributor.authorHübner, Marc P.
dc.contributor.authorHildner, Kai
dc.contributor.authorHoerauf, Achim
dc.contributor.authorDunay, Ildiko Rita
dc.contributor.authorSchumak, Beatrix
dc.date.accessioned2020-12-30
dc.date.available2023-10-09T18:32:40Z
dc.date.created2020
dc.date.issued2020-12-30
dc.description.abstractExcessive inflammatory immune responses during infections with Plasmodium parasites are responsible for severe complications such as cerebral malaria (CM) that can be studied experimentally in mice. Dendritic cells (DCs) activate cytotoxic CD8+ T‐cells and initiate immune responses against the parasites. Batf3−/− mice lack a DC subset, which efficiently induces strong CD8 T‐cell responses by cross‐presentation of exogenous antigens. Here we show that Batf3−/− mice infected with Plasmodium berghei ANKA (PbA) were protected from experimental CM (ECM), characterized by a stable blood−brain barrier (BBB) and significantly less infiltrated peripheral immune cells in the brain. Importantly, the absence of ECM in Batf3−/− mice correlated with attenuated responses of cytotoxic T‐cells, as their parasite‐specific lytic activity as well as the production of interferon gamma and granzyme B were significantly decreased. Remarkably, spleens of ECM‐protected Batf3−/− mice had elevated levels of regulatory immune cells and interleukin 10. Thus, protection from ECM in PbA‐infected Batf3−/− mice was associated with the absence of strong CD8+ T‐cell activity and induction of immunoregulatory mediators and cells.en
dc.format.extent11
dc.identifier.citationImmunology 159.2 (2020): S. 193-204. <https://onlinelibrary.wiley.com/doi/full/10.1111/imm.13137>
dc.identifier.doihttps://doi.org/10.1111/imm.13137
dc.identifier.opus-id15338
dc.identifier.urihttps://open.fau.de/handle/openfau/15338
dc.identifier.urnurn:nbn:de:bvb:29-opus4-153382
dc.language.isoen
dc.publisherJohn Wiley & Sons Ltd
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.de
dc.subjectexperimental cerebral malaria
dc.subjectdendritic cells
dc.subjectinflammation
dc.subjectT‐cells
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleProtection of Batf3‐deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T‐cell responses and immune regulationen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.date.prevpublished2020-01-11
local.document.pageend204
local.document.pagestart193
local.journal.issue2
local.journal.titleImmunology
local.journal.volume159
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät
local.subject.importimport
local.subject.sammlungUniversität Erlangen-Nürnberg / Eingespielte Open Access Artikel / Eingespielte Open Access Artikel 2020
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