Incorporation of Zinc into Binary SiO2-CaO Mesoporous Bioactive Glass Nanoparticles Enhances Anti-Inflammatory and Osteogenic Activities

dc.contributor.authorSun, Haishui
dc.contributor.authorZheng, Kai
dc.contributor.authorZhou, Tian
dc.contributor.authorBoccaccini, Aldo R.
dc.date.accessioned2022-01-07
dc.date.available2023-10-16T20:15:32Z
dc.date.created2021
dc.date.issued2022-01-07
dc.description.abstractDuring the healing and repair of bone defects, uncontrolled inflammatory responses can compromise bone regeneration. Biomaterials with anti-inflammatory activity are favorable for bone tissue regeneration processes. In this work, multifunctional Zn-containing mesoporous bioactive glass nanoparticles (Zn-MBGs) exhibiting favorable osteogenic and anti-inflammatory activities were produced employing a sol-gel method. Zn-MBGs exhibited a mesoporous spherical shape and nanoscale particle size (100 ± 20 nm). They were degradable in cell culture medium, and could release Si, Ca, and Zn in a sustained manner. Zn-MBGs also exhibited a concentration-dependent cellular response. The extract of Zn-MBGs obtained by incubation at 0.1 mg/mL (in culture medium) for 24 h could enhance in vitro mineralization, alkaline phosphatase activity, the expression of osteogenesis-related genes, and the production of intracellular protein osteocalcin of rat bone marrow stromal cells (BMSCs). Moreover, the extract of Zn-MBGs at 0.1 mg/mL could significantly downregulate the expression of inflammatory genes and the production of inducible nitric oxide in RAW 264.7 cells, particularly under stimulation of inflammatory signals interferon-γ (IFN-γ) and lipopolysaccharide (LPS). Zn-MBGs also inhibited the pro-inflammatory M1 polarization of RAW264.7 cells induced by LPS and IFN-γ. In summary, we successfully synthesized Zn-MBGs with concentration-dependent osteogenic and anti-inflammatory activities. Zn-MBGs show their great potential in immunomodulation strategies for bone regeneration, representing a multifunctional biomaterial that can be applied to regenerate bone defects under inflammatory conditions.en
dc.identifier.citationPharmaceutics 13.12 (2021): 2124. <https://www.mdpi.com/1999-4923/13/12/2124>
dc.identifier.doihttps://doi.org/10.3390/pharmaceutics13122124
dc.identifier.issn1999-4923
dc.identifier.opus-id18028
dc.identifier.urihttps://open.fau.de/handle/openfau/18028
dc.identifier.urnurn:nbn:de:bvb:29-opus4-180286
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.de
dc.subjectzinc
dc.subjectbioactive glasses
dc.subjectanti-inflammatory
dc.subjectosteogenic differentiation
dc.subjectimmunomodulation
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 62 Ingenieurwissenschaften :: 620 Ingenieurwissenschaften und zugeordnete Tätigkeiten
dc.titleIncorporation of Zinc into Binary SiO2-CaO Mesoporous Bioactive Glass Nanoparticles Enhances Anti-Inflammatory and Osteogenic Activitiesen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.date.prevpublished2021-12-09
local.document.articlenumber2124
local.journal.issue12
local.journal.titlePharmaceutics
local.journal.volume13
local.sendToDnbfree*
local.subject.fakultaetTechnische Fakultät
local.subject.importimport
local.subject.sammlungUniversität Erlangen-Nürnberg / Eingespielte Open Access Artikel / Eingespielte Open Access Artikel 2022
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