Magnetite-Arginine Nanoparticles as a Multifunctional Biomedical Tool

dc.contributor.authorReichel, Victoria E.
dc.contributor.authorMatuszak, Jasmin
dc.contributor.authorBente, Klaas
dc.contributor.authorHeil, Tobias
dc.contributor.authorKraupner, Alexander
dc.contributor.authorDutz, Silvio
dc.contributor.authorCicha, Iwona
dc.contributor.authorFaivre, Damien
dc.date.accessioned2020-12-29
dc.date.available2023-10-09T18:25:54Z
dc.date.created2020
dc.date.issued2020-12-29
dc.description.abstractIron oxide nanoparticles are a promising platform for biomedical applications, both in terms of diagnostics and therapeutics. In addition, arginine-rich polypeptides are known to penetrate across cell membranes. Here, we thus introduce a system based on magnetite nanoparticles and the polypeptide poly-l-arginine (polyR-Fe3O4). We show that the hybrid nanoparticles exhibit a low cytotoxicity that is comparable to Resovist®, a commercially available drug. PolyR-Fe3O4 particles perform very well in diagnostic applications, such as magnetic particle imaging (1.7 and 1.35 higher signal respectively for the 3rd and 11th harmonic when compared to Resovist®), or as contrast agents for magnetic resonance imaging (R2/R1 ratio of 17 as compared to 11 at 0.94 T for Resovist®). Moreover, these novel particles can also be used for therapeutic purposes such as hyperthermia, achieving a specific heating power ratio of 208 W/g as compared to 83 W/g for Feridex®, another commercially available product. Therefore, we envision such materials to play a role in the future theranostic applications, where the arginine ability to deliver cargo into the cell can be coupled to the magnetite imaging properties and cancer fighting activity.en
dc.identifier.citationNanomaterials 10.10 (2020). <https://www.mdpi.com/2079-4991/10/10/2014>
dc.identifier.doihttps://doi.org/10.3390/nano10102014
dc.identifier.issn2079-4991
dc.identifier.opus-id15197
dc.identifier.urihttps://open.fau.de/handle/openfau/15197
dc.identifier.urnurn:nbn:de:bvb:29-opus4-151974
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.de
dc.subjectiron oxide
dc.subjectnanoparticle
dc.subjecttheranostics
dc.subjectMRI
dc.subjecthyperthermia
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleMagnetite-Arginine Nanoparticles as a Multifunctional Biomedical Toolen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.date.prevpublished2020-10-13
local.journal.issue10
local.journal.titleNanomaterials
local.journal.volume10
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät
local.subject.importimport
local.subject.sammlungUniversität Erlangen-Nürnberg / Eingespielte Open Access Artikel / Eingespielte Open Access Artikel 2020
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