A Proposal to Perform High Contrast Imaging of Human Palatine Tonsil with Cross Polarized Optical Coherence Tomography

dc.contributor.authorSharma, Gargi
dc.contributor.authorParmar, Asha
dc.contributor.authorHoffmann, Franziska
dc.contributor.authorGeißler, Katharina
dc.contributor.authorvon Eggeling, Ferdinand
dc.contributor.authorGuntinas-Lichius, Orlando
dc.contributor.authorSingh, Kanwarpal
dc.date.accessioned2022-05-09
dc.date.available2023-10-11T12:48:14Z
dc.date.created2022
dc.date.issued2022-05-09
dc.description.abstractThe palatine tonsils provide the first line of immune defense against foreign pathogens inhaled or ingested. However, a disruption in the epithelial layer within the tonsil crypts can lead to recurrent acute tonsillitis (RAT). Current imaging techniques suffer from poor resolution and contrast and do not allow a classification of the severity of RAT. We have developed a cross-polarized optical coherence tomography system. The system can detect a change in the polarization of the light after the light-tissue interaction. We demonstrate improved resolution and contrast in tonsil imaging with the developed method. Intensity, as well as retardance images of the excised tonsil tissue, were acquired. Features such as crypt epithelium, lymphoid follicles, and dense connective tissue were observed with improved contrast. Cross polarized optical coherence tomography can be a valuable tool in the clinic to evaluate palatine tonsils as it would allow visualizing common tonsil features without the need for any external contrast agent.en
dc.identifier.citationPhotonics 9.4 (2022): 259. <https://www.mdpi.com/2304-6732/9/4/259>
dc.identifier.doihttps://doi.org/10.3390/photonics9040259
dc.identifier.issn2304-6732
dc.identifier.opus-id19216
dc.identifier.urihttps://open.fau.de/handle/openfau/19216
dc.identifier.urnurn:nbn:de:bvb:29-opus4-192168
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.de
dc.subjectpalatine tonsils
dc.subjectlabel-free imaging
dc.subjecttonsillitis
dc.subjectchronic inflammation
dc.subjectcross-polarized optical coherence tomography
dc.subjectbiomedical imaging
dc.subject.ddcDDC Classification::5 Naturwissenschaften und Mathematik :: 53 Physik :: 530 Physik
dc.titleA Proposal to Perform High Contrast Imaging of Human Palatine Tonsil with Cross Polarized Optical Coherence Tomographyen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.date.prevpublished2022-04-13
local.document.articlenumber259
local.journal.issue4
local.journal.titlePhotonics
local.journal.volume9
local.sendToDnbfree*
local.subject.fakultaetNaturwissenschaftliche Fakultät
local.subject.importimport
local.subject.sammlungUniversität Erlangen-Nürnberg / Eingespielte Open Access Artikel / Eingespielte Open Access Artikel 2022
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