Dual-source computed tomography of the lung with spectral shaping and advanced iterative reconstruction: potential for maximum radiation dose reduction

dc.contributor.authorWetzl, Matthias
dc.contributor.authorMay, Matthias S.
dc.contributor.authorWeinmann, Daniel
dc.contributor.authorHammon, Matthias
dc.contributor.authorTreutlein, Christoph
dc.contributor.authorZeilinger, Martin
dc.contributor.authorKiefer, Alexander
dc.contributor.authorTrollmann, Regina
dc.contributor.authorWoelfle, Joachim
dc.contributor.authorUder, Michael
dc.contributor.authorRompel, Oliver
dc.date.accessioned2023-05-24
dc.date.available2023-10-09T22:01:59Z
dc.date.created2020
dc.date.issued2023-05-24
dc.description.abstractAbstract Background Radiation dose at CT should be as low as possible without compromising diagnostic quality. Objective To assess the potential for maximum dose reduction of pediatric lung dual-source CT with spectral shaping and advanced iterative reconstruction (ADMIRE). Materials and methods We retrospectively analyzed dual-source CT acquisitions in a full-dose group (FD: 100 kV, 64 reference mAs) and in three groups with spectral shaping and differing reference mAs values (Sn: 100 kV, 96/64/32 reference mAs), each group consisting of 16 patients (age mean 11.5 years, standard deviation 4.8 years, median 12.8 years, range 1.3–18 years). Advanced iterative reconstruction of images was performed with different strengths (FD: ADMIRE Level 2; Sn: ADMIRE Levels 2, 3 and 4). We analyzed dose parameters and measured noise. Diagnostic confidence and detectability of lung lesions as well as anatomical structures were assessed using a Likert scale (from 1 [unacceptable] to 4 [fully acceptable]). Results Compared to full dose, effective dose was reduced to 16.7% in the Sn 96 group, 11.1% in Sn64, and 5.5% in Sn32 (P<0.001). Noise values of Sn64ADM4 did not statistically differ from those in FDADM2 (45.7 vs. 38.9 Hounsfield units [HU]; P=0.132), whereas noise was significantly higher in Sn32ADM4 compared to Sn64ADM4 (61.5 HU; P<0.001). A Likert score >3 was reached in Sn64ADM4 regarding diagnostic confidence (3.2) and detectability of lung lesions (3.3). For detectability of most anatomical structures, no significant differences were found between FDAM2 and Sn64ADM4 (P≥0.05). Conclusion In pediatric lung dual-source CT, spectral shaping together with ADMIRE 4 enable radiation dose reduction to about 10% of a full-dose protocol while maintaining an acceptable diagnostic quality.en
dc.format.extent8
dc.identifier.citationPediatric Radiology 50.9 (2020): 1240-1248. <https://link.springer.com/article/10.1007/s00247-020-04714-0>
dc.identifier.doihttps://doi.org/10.1007/s00247-020-04714-0
dc.identifier.issn0301-0449
dc.identifier.issn1432-1998
dc.identifier.opus-id22996
dc.identifier.urihttps://open.fau.de/handle/openfau/22996
dc.identifier.urnurn:nbn:de:bvb:29-opus4-229967
dc.language.isoen
dc.publisherSpringer Berlin Heidelberg
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.de
dc.subjectAdolescents
dc.subjectAdvanced iterative reconstruction
dc.subjectChildren
dc.subjectDual-source computed tomography
dc.subjectTin prefiltration
dc.subjectLung
dc.subjectRadiation dose reduction
dc.subjectSpectral shaping
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleDual-source computed tomography of the lung with spectral shaping and advanced iterative reconstruction: potential for maximum radiation dose reductionen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.date.prevpublished2020-08-01
local.document.pageend1248
local.document.pagestart1240
local.journal.issue9
local.journal.titlePediatric Radiology
local.journal.volume50
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät
local.subject.importimport
local.subject.sammlungUniversität Erlangen-Nürnberg / Eingespielte Open Access Artikel / Eingespielte Open Access Artikel 2023
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