Biomechanical stress in the context of competitive sports training triggers enthesitis

dc.contributor.authorSimon, David
dc.contributor.authorKleyer, Arnd
dc.contributor.authorBayat, Sara
dc.contributor.authorKnitza, Johannes
dc.contributor.authorValor-Mendez, Larissa
dc.contributor.authorSchweiger, Marina
dc.contributor.authorSchett, Georg
dc.contributor.authorTascilar, Koray
dc.contributor.authorHueber, Axel J.
dc.date.accessioned2021-11-16
dc.date.available2021-11-15
dc.date.created2021
dc.date.issued2021-11-16
dc.description.abstractObjective To evaluate the influence of mechanical stress on the development of immediate enthesitis. Methods The BEAT study is an interventional study that assessed entheses in competitive badminton players before and immediately after a 60-min intensive training session. Power Doppler (PD) signal and Gray scale (GS) changes were assessed in the insertion sites of both Achilles tendon, patellar tendons, and lateral humeral epicondyles and quantified using a validated scoring system. Results Thirty-two badminton players were included. One hundred ninety-two entheseal sites were examined twice. The respective empirical total scores for PD examination were 0.1 (0.3) before and 0.5 (0.9) after training. Mean total GS scores were 2.9 (2.5) and 3.1 (2.5) before and after training, respectively. The mean total PD score difference of 0.4 between pre- and post-training was significant (p = 0.0014), whereas no significant difference for the mean total GS score was observed. Overall, seven participants (22%) showed an increased empirical total PD score. A mixed effects model showed a significant increase of PD scores after training, with a mean increase per site of 0.06 (95% CI 0.01 to 0.12, p = 0.017). Conclusions Mechanical stress leads to rapid inflammatory responses in the entheseal structures of humans. These data support the concept of mechanoinflammation in diseases associated with enthesitis.en
dc.identifier.citationArthritis Research & Therapy 23 (2021): 172. <https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-021-02530-x>
dc.identifier.doihttps://doi.org/10.1186/s13075-021-02530-x
dc.identifier.opus-id17565
dc.identifier.urihttps://open.fau.de/handle/openfau/17565
dc.identifier.urnurn:nbn:de:bvb:29-opus4-175655
dc.language.isoen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.de
dc.subjectEnthesitis
dc.subjectBiomechanical stress
dc.subjectInflammation
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleBiomechanical stress in the context of competitive sports training triggers enthesitisen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.document.articlenumber172
local.journal.titleArthritis Research & Therapy
local.journal.volume23
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät
local.subject.sammlungUniversität Erlangen-Nürnberg / Von der FAU geförderte Open Access Artikel / Von der FAU geförderte Open Access Artikel 2021
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