Low-Dose Radiotherapy Has No Harmful Effects on Key Cells of Healthy Non-Inflamed Joints

dc.contributor.authorDeloch, Lisa
dc.contributor.authorRückert, Michael
dc.contributor.authorFietkau, Rainer
dc.contributor.authorFrey, Benjamin
dc.contributor.authorGaipl, Udo S.
dc.date.accessioned2019-05-10
dc.date.available2019-05-08
dc.date.created2018
dc.date.issued2019-05-10
dc.description.abstractLow-dose radiotherapy (LD-RT) for benign inflammatory and/or bone destructive diseases has been used long. Therefore, mechanistic investigations on cells being present in joints are mostly made in an inflammatory setting. This raises the question whether similar effects of LD-RT are also seen in healthy tissue and thus might cause possible harmful effects. We performed examinations on the functionality and phenotype of key cells within the joint, namely on fibroblast-like synoviocytes (FLS), osteoclasts and osteoblasts, as well as on immune cells. Low doses of ionizing radiation showed only a minor impact on cytokine release by healthy FLS as well as on molecules involved in cartilage and bone destruction and had no significant impact on cell death and migration properties. The bone resorbing abilities of healthy osteoclasts was slightly reduced following LD-RT and a positive impact on bone formation of healthy osteoblasts was observed after in particular exposure to 0.5 Gray (Gy). Cell death rates of bone-marrow cells were only marginally increased and immune cell composition of the bone marrow showed a slight shift from CD8+ to CD4+ T cell subsets. Taken together, our results indicate that LD-RT with particularly a single dose of 0.5 Gy has no harmful effects on cells of healthy joints.en
dc.identifier.citationInternational Journal of Molecular Sciences 19.10 (2018). <https://doi.org/10.3390/ijms19103197>
dc.identifier.doihttps://doi.org/10.3390/ijms19103197
dc.identifier.opus-id11010
dc.identifier.urihttps://open.fau.de/handle/openfau/11010
dc.identifier.urnurn:nbn:de:bvb:29-opus4-110105
dc.language.isoen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.de
dc.subjectlow-dose radiotherapy
dc.subjectfibroblast-like synoviocytes
dc.subjectosteoclasts
dc.subjectosteoblasts
dc.subjectimmune cells
dc.subjectjoint
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleLow-Dose Radiotherapy Has No Harmful Effects on Key Cells of Healthy Non-Inflamed Jointsen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.journal.issue10
local.journal.titleInternational Journal of Molecular Sciences
local.journal.volume19
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät
local.subject.sammlungUniversität Erlangen-Nürnberg / Von der FAU geförderte Open Access Artikel / Von der FAU geförderte Open Access Artikel 2018
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