Shigella Outer Membrane Vesicles as Promising Targets for Vaccination

dc.contributor.authorQasim, Muhammad
dc.contributor.authorWrage, Marius
dc.contributor.authorNüse, Björn
dc.contributor.authorMattner, Jochen
dc.date.accessioned2022-10-20
dc.date.available2023-10-09T22:40:07Z
dc.date.created2022
dc.date.issued2022-10-20
dc.description.abstractThe clinical symptoms of shigellosis, a gastrointestinal infection caused by Shigella spp. range from watery diarrhea to fulminant dysentery. Endemic infections, particularly among children in developing countries, represent the majority of clinical cases. The situation is aggravated due to the high mortality rate of shigellosis, the rapid dissemination of multi-resistant Shigella strains and the induction of only serotype-specific immunity. Thus, infection prevention due to vaccination, encompassing as many of the circulating serotypes as possible, has become a topic of interest. However, vaccines have turned out to be ineffective so far. Outer membrane vesicles (OMVs) are promising novel targets for vaccination. OMVs are constitutively secreted by Gram-negative bacteria including Shigella during growth. They are composed of soluble luminal portions and an insoluble membrane and can contain toxins, bioactive periplasmic and cytoplasmic (lipo-) proteins, (phospho-) lipids, nucleic acids and/or lipopolysaccharides. Thus, OMVs play an important role in bacterial cell–cell communication, growth, survival and pathogenesis. Furthermore, they modulate the secretion and transport of biomolecules, the stress response, antibiotic resistance and immune responses of the host. Thus, OMVs serve as novel secretion machinery. Here, we discuss the current literature and highlight the properties of OMVs as potent vaccine candidates because of their immunomodulatory, antigenic and adjuvant properties.en
dc.identifier.citationInternational Journal of Molecular Sciences 23.2 (2022): 994. <https://www.mdpi.com/1422-0067/23/2/994>
dc.identifier.doihttps://doi.org/10.3390/ijms23020994
dc.identifier.issn1422-0067
dc.identifier.opus-id20657
dc.identifier.urihttps://open.fau.de/handle/openfau/20657
dc.identifier.urnurn:nbn:de:bvb:29-opus4-206575
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.de
dc.subjectouter membrane vesicles (OMVs)
dc.subjectvaccination
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleShigella Outer Membrane Vesicles as Promising Targets for Vaccinationen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.date.prevpublished2022-01-17
local.document.articlenumber994
local.journal.issue2
local.journal.titleInternational Journal of Molecular Sciences
local.journal.volume23
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät
local.subject.importimport
local.subject.sammlungUniversität Erlangen-Nürnberg / Eingespielte Open Access Artikel / Eingespielte Open Access Artikel 2022
local.subject.sammlungUniversität Erlangen-Nürnberg / Von der FAU geförderte Open Access Artikel / Von der FAU geförderte Open Access Artikel 2022
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