Shigella Outer Membrane Vesicles as Promising Targets for Vaccination

Language
en
Document Type
Article
Issue Date
2022-10-20
First published
2022-01-17
Issue Year
2022
Authors
Qasim, Muhammad
Wrage, Marius
Nüse, Björn
Mattner, Jochen
Editor
Publisher
MDPI
Abstract

The clinical symptoms of shigellosis, a gastrointestinal infection caused by Shigella spp. range from watery diarrhea to fulminant dysentery. Endemic infections, particularly among children in developing countries, represent the majority of clinical cases. The situation is aggravated due to the high mortality rate of shigellosis, the rapid dissemination of multi-resistant Shigella strains and the induction of only serotype-specific immunity. Thus, infection prevention due to vaccination, encompassing as many of the circulating serotypes as possible, has become a topic of interest. However, vaccines have turned out to be ineffective so far. Outer membrane vesicles (OMVs) are promising novel targets for vaccination. OMVs are constitutively secreted by Gram-negative bacteria including Shigella during growth. They are composed of soluble luminal portions and an insoluble membrane and can contain toxins, bioactive periplasmic and cytoplasmic (lipo-) proteins, (phospho-) lipids, nucleic acids and/or lipopolysaccharides. Thus, OMVs play an important role in bacterial cell–cell communication, growth, survival and pathogenesis. Furthermore, they modulate the secretion and transport of biomolecules, the stress response, antibiotic resistance and immune responses of the host. Thus, OMVs serve as novel secretion machinery. Here, we discuss the current literature and highlight the properties of OMVs as potent vaccine candidates because of their immunomodulatory, antigenic and adjuvant properties.

Journal Title
International Journal of Molecular Sciences
Volume
23
Issue
2
Citation
International Journal of Molecular Sciences 23.2 (2022): 994. <https://www.mdpi.com/1422-0067/23/2/994>
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