Predicting Prognosis of Breast Cancer Patients with Brain Metastases in the BMBC Registry—Comparison of Three Different GPA Prognostic Scores

Language
en
Document Type
Article
Issue Date
2021-03-04
First published
2021-02-17
Issue Year
2021
Authors
Riecke, Kerstin
Müller, Volkmar
Weide, Rudolf
Schmidt, Marcus
Park-Simon, Tjoung-Won
Möbus, Volker
Mundhenke, Christoph
Polasik, Arkadius
Lübbe, Kristina
Hesse, Tobias
Editor
Publisher
MDPI
Abstract

Several scores have been developed in order to estimate the prognosis of patients with brain metastases (BM) by objective criteria. The aim of this analysis was to validate all three published graded-prognostic-assessment (GPA)-scores in a subcohort of 882 breast cancer (BC) patients with BM in the Brain Metastases in the German Breast Cancer (BMBC) registry. The median age at diagnosis of BM was 57 years. All in all, 22.3% of patients (n = 197) had triple-negative, 33.4% (n = 295) luminal A like, 25.1% (n = 221) luminal B/HER2-enriched like and 19.2% (n = 169) HER2 positive like BC. Age ≥60 years, evidence of extracranial metastases (ECM), higher number of BM, triple-negative subtype and low Karnofsky-Performance-Status (KPS) were all associated with worse overall survival (OS) in univariate analysis (p < 0.001 each). All three GPA-scores were associated with OS. The breast-GPA showed the highest probability of classifying patients with survival above 12 months in the best prognostic group (specificity 68.7% compared with 48.1% for the updated breast-GPA and 21.8% for the original GPA). Sensitivities for predicting 3 months survival were very low for all scores. In this analysis, all GPA-scores showed only moderate diagnostic accuracy in predicting the OS of BC patients with BM.

Journal Title
Cancers
Volume
13
Issue
4
Citation
Cancers 13.4 (2021): 844. <https://www.mdpi.com/2072-6694/13/4/844>
Zugehörige ORCIDs