Gingiva thickening with a porcine collagen matrix in a preclinical dog model: Histological outcomes

Language
en
Document Type
Article
Issue Date
2020-12-29
First published
2019-11-14
Issue Year
2019
Authors
Schmitt, Christian M.
Schlegel, Karl Andreas
Gammel, Lisa
Moest, Tobias
Editor
Publisher
John Wiley & Sons Ltd
Abstract

Aim To compare 10‐month histological and immunohistological outcomes after soft tissue thickening around teeth with a porcine collagen matrix (CM) versus a subepithelial connective tissue graft (SCTG).

Material and Methods In eight beagle dogs, soft tissue thickening of the buccal gingiva of upper canines was performed with the SCTG or the CM. Connective tissue thickness (CTT) was histomorphometrically measured in the augmented regions. The augmented connective tissues were also histologically characterized and the collagen I and vascular endothelial growth factor (VEGF) expressions immunohistologically quantified.

Results CTT significantly differed between groups (SCTG: 1.32 mm ± 0.44 mm; CM: 1.06 mm ± 0.27 mm; p = .008). Descriptive histological analyses revealed mature connective tissue that did not differ between groups. Immunohistological quantification of collagen I and VEGF expressions in the connective tissue also revealed no significant inter‐group differences (collagen I: SCTG, 32.64% ± 7.09% vs. CM, 30.57% ± 7.83%; VEGF: SCTG, 39.06% ± 7.27% vs. CM, 37.15% ± 9.80%).

Conclusion SCTG is superior to CM with regard to CTT in this experimental model. The CM and the SCTG lead to comparable connective tissue quality ten months after connective tissue thickening.

Journal Title
Journal of Clinical Periodontology
Volume
46
Issue
12
Citation
Journal of Clinical Periodontology 46.12 (2019): S. 1273-1281. <https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13196>
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