Increase in β-Amyloid Levels in Cerebrospinal Fluid of Children with Down Syndrome

dc.contributor.authorEnglund, Hillevi
dc.contributor.authorAnnerén, Göran
dc.contributor.authorGustafsson, Jan
dc.contributor.authorWester, Ulrika
dc.contributor.authorWiltfang, Jens
dc.contributor.authorLannfelt, Lars
dc.contributor.authorBlennow, Kaj
dc.contributor.authorHöglund, Kina
dc.description.abstractBackground: Individuals with Down syndrome (DS) invariably develop Alzheimer’s disease (AD) during their life span. It is therefore of importance to study young DS patients when trying to elucidate early events in AD pathogenesis. Aim: To investigate how levels of different amyloid- _ (A _ ) peptides, as well as tau and phosphorylated tau, in cerebrospinal fluid (CSF) from children with DS change over time. The first CSF sample was taken at 8 months and the following two samples at 20–40 and 54 months of age. Results: Individual levels of the A _ peptides, as well as total A _ levels in CSF increased over time when measured with Western blot. Tau in CSF decreased whereas there was no change in levels of phosphorylated tau over time. Conclusion: The increasing levels of A _ in CSF during early childhood of DS patients observed in this study are probably due to the trisomy of the A _ precursor APP, which leads to an overproduction of A _ . Despite the increased CSF concentrations of A _ , there were no signs of an AD-indicating tau pattern in CSF, since the levels of total tau decreased and phosphorylated tau remained unchanged. This observation further strengthens the theory of A _ pathology preceding tau pathology in AD.en
dc.identifier.citationDementia and Geriatric Cognitive Disorders 2007; 24: 369-374. <> © 2007 S. Karger AG, Basel
dc.subjectAlzheimer’s disease
dc.subjectDown syndrome
dc.subjectTau Cerebrospinal fluid
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleIncrease in β-Amyloid Levels in Cerebrospinal Fluid of Children with Down Syndromeen
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.journal.titleDementia and Geriatric Cognitive Disorders 2007; 24: 369-374. <> © 2007 S. Karger AG, Basel
local.subject.fakultaetMedizinische Fakultät / Medizinische Fakultät -ohne weitere Spezifikation-
local.subject.sammlungUniversität Erlangen-Nürnberg / Nationallizenzen: Alle Beiträge sind mit Zustimmung der Rechteinhaber aufgrund einer DFG-geförderten Nationallizenz frei zugänglich. / Nationallizenzen 2007
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
157.85 KB
Adobe Portable Document Format