Macrophages in homeostatic immune function

Language
en
Document Type
Article
Issue Date
2020-01-17
First published
2014-05-05
Issue Year
2014
Authors
Jantsch, Jonathan
Binger, Katrina J.
Müller, Dominik N.
Titze, Jens
Editor
Publisher
Frontiers Media S.A.
Abstract

Macrophages are not only involved in inflammatory and anti-infective processes, but also play an important role in maintaining tissue homeostasis. In this review, we summarize recent evidence investigating the role of macrophages in controlling angiogenesis, metabolism as well as salt and water balance. Particularly, we summarize the importance of macrophage tonicity enhancer binding protein (TonEBP, also termed nuclear factor of activated T-cells 5 [NFAT5]) expression in the regulation of salt and water homeostasis. Further understanding of homeostatic macrophage function may lead to new therapeutic approaches to treat ischemia, hypertension and metabolic disorders.

Journal Title
Frontiers in Physiology
Volume
5
Citation
Frontiers in Physiology 5 (2014). <https://www.frontiersin.org/articles/10.3389/fphys.2014.00146/full>
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