High-definition endoscopy with digital chromoendoscopy for histologic prediction of distal colorectal polyps

dc.contributor.authorRath, Timo
dc.contributor.authorTontini, Gian E.
dc.contributor.authorNägel, Andreas
dc.contributor.authorVieth, Michael
dc.contributor.authorZopf, Steffen
dc.contributor.authorGünther, Claudia
dc.contributor.authorHoffman, Arthur
dc.contributor.authorNeurath, Markus F.
dc.contributor.authorNeumann, Helmut
dc.date.accessioned2016-07-25
dc.date.available2016-07-25
dc.date.created2015
dc.date.issued2016-07-25
dc.description.abstractBackground Distal diminutive colorectal polyps are common and accurate endoscopic prediction of hyperplastic or adenomatous polyp histology could reduce procedural time, costs and potential risks associated with the resection. Within this study we assessed whether digital chromoendoscopy can accurately predict the histology of distal diminutive colorectal polyps according to the ASGE PIVI statement. Methods In this prospective cohort study, 224 consecutive patients undergoing screening or surveillance colonoscopy were included. Real time histology of 121 diminutive distal colorectal polyps was evaluated using high-definition endoscopy with digital chromoendoscopy and the accuracy of predicting histology with digital chromoendoscopy was assessed. Results The overall accuracy of digital chromoendoscopy for prediction of adenomatous polyp histology was 90.1 %. Sensitivity, specificity, positive and negative predictive values were 93.3, 88.7, 88.7, and 93.2 %, respectively. In high-confidence predictions, the accuracy increased to 96.3 % while sensitivity, specificity, positive and negative predictive values were calculated as 98.1, 94.4, 94.5, and 98.1 %, respectively. Surveillance intervals with digital chromoendoscopy were correctly predicted with >90 % accuracy. Conclusions High-definition endoscopy in combination with digital chromoendoscopy allowed real-time in vivo prediction of distal colorectal polyp histology and is accurate enough to leave distal colorectal polyps in place without resection or to resect and discard them without pathologic assessment. This approach has the potential to reduce costs and risks associated with the redundant removal of diminutive colorectal polyps.en
dc.identifier.citationBMC Gastroenterology 15(2015):S.145-152. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619024/>
dc.identifier.opus-id7278
dc.identifier.urihttps://open.fau.de/handle/openfau/7278
dc.identifier.urnurn:nbn:de:bvb:29-opus4-72786
dc.language.isoen
dc.rights.urihttp://www.gesetze-im-internet.de/urhg/index.html
dc.subjectAdenomas
dc.subjectColorectal cancer
dc.subjectGastrointestinal endoscopy
dc.subjectHistology
dc.subjectPolyps
dc.subject.ddcDDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit
dc.titleHigh-definition endoscopy with digital chromoendoscopy for histologic prediction of distal colorectal polypsen
dc.typearticle
dcterms.publisherFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
local.journal.issue145-152
local.journal.titleBMC Gastroenterology
local.journal.volume15
local.sendToDnbfree*
local.subject.fakultaetMedizinische Fakultät
local.subject.gnd-
local.subject.sammlungUniversität Erlangen-Nürnberg / Von der FAU geförderte Open Access Artikel / Von der FAU geförderte Open Access Artikel 2015
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
7278_rath_high-definition.pdf
Size:
609.82 KB
Format:
Adobe Portable Document Format
Description: