Zinc Gluconate in the Treatment of Dysgeusia—a Randomized Clinical Trial

Language
en
Document Type
Article
Issue Date
2013-02-18
Issue Year
2005
Authors
Heckmann, Siegfried Martin
Hujoel, P.
Habiger, S.
Friess, W.
Wichmann, Manfred
Heckmann, Josef G.
Hummel, T.
Editor
Abstract

In the treatment of dysgeusia, the use of zinc has been frequently tried, with equivocal results. The aim of the present randomized clinical trial, which involved a sufficiently large sample, was therefore to determine the efficacy of zinc treatment. Fifty patients with idiopathic dysgeusia were carefully selected. Zinc gluconate (140 mg/day; n = 26) or placebo (lactose; n = 24) was randomly assigned to the patients. The patients on zinc improved in terms of gustatory function (p < 0.001) and rated the dysgeusia as being less severe (p < 0.05). Similarly, signs of depression in the zinc group were less severe (Beck Depression Inventory, p < 0.05; mood scale, p < 0.05). With the exception of the salivary calcium level, which was higher in the zinc patients (p < 0.05), no other significant group differences were found. In conclusion, zinc appears to improve general gustatory function and, consequently, general mood scores in dysgeusia patients.

Journal Title
Journal of Dental Research 84.1 (2005): S. 35-38. 30.01.2013 <http://jdr.sagepub.com/content/84/1/35>
Citation
Journal of Dental Research 84.1 (2005): S. 35-38. 30.01.2013 <http://jdr.sagepub.com/content/84/1/35>
DOI
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